FSL 816 - Seminários em pirexia: aspectos farmacológicos - M/DFSL 816 - SEMINÁRIOS EM PIREXIA: ASPECTOS FARMACOLÓGICOS (02-00) 2 - 30
Prof. Dr. Carlos Fernando de Mello
OBJETIVOS: Propiciar informações sobre mecanismos de regulação da temperatura corporal, bem como da ação de fármacos sobre a temperatura corporal.
EMENTA: Mecanismos neuroquímicos de regulação de temperatura corporal e ação de fármacos moduladores de tais mecanismos fisiológicos em situações patológicas.
METODOLOGIA E/OU INSTRUMENTOS DE ENSINO:
Seminários individuais, discussão de artigos científicos, aulas expositivas e práticas, quadro, equipamento audiovisual (data show).
FORMA DE AVALIAÇÃO:
Seminários, participação em aulas, pontualidade, assiduidade e auto-avaliação.
PROGRAMA
UNIDADE 1. Mecanismos de controle da temperatura corporal.
1.1. O conceito de termostato biológico
1.1.1 A área pré-óptica do hipotálamo
1.2. Efetores do sistema hipotalâmico
1.2.1. Sistema simpático e parassimpático
1.2.2. Eixo hipotálamo-hipófise-adrenal
UNIDADE 2. Pirógenos Exógenos
2.1 Lipopolissacarídeo
2.2 Papel do nervo vago na pirexia induzida por LPS
2.3 Mannans
2.4 Turpentina
UNIDADE 3. Pirógenos endógenos
3.1 Citocinas
3.2 Prostaglandinas
UNIDADE 4. Criógenos exógenos
4.1 Vanilóides
UNIDADE 5. Neurotransmissores envolvidos na termorregulação
5.1 Acetilcolina
5.2 Noradrenalina
5.3 Dopamina
5.4 Opióides
5.5 Serotonina
5.6 Glutamato
5.7 GABA
5.8 Óxido nítrico
5.9 MSH
5.10 Arg-vasopressina
UNIDADE 6. Proteínas Cinases e termorregulação
6.1 Proteína Cinase A
6.2 Proteína Cinase G
6.3 Tirosina cinases
BIBLIOGRAFIA:
Adam D, Stankov G. Treatment of fever in childhood. Eur. J. Pediatr. 153, 394-402, 1994.
Benamar K, Xin L, Geller EB, Adler MW. Blockade of lipopolysaccharide-induced fever by a -opioid receptor-selective antagonist in rats. Eur. J. Pharmacol. 401, 161-165, 2000.
Blanque´ R, Meakin C, Millet S, Gardner CR. Dual mechanisms of action of interferon-g in potentiating responses to LPS in mice IL1, TNF and IL6 production in serum and hypothermia. Gen. Pharmacol. 32, 453-461, 1999.
Cao C, Matsumura K, Yamagata K, Watanabe Y. Involvement of cyclooxygenase-2 in LPS-induced fever and regulation of its mRNA by LPS in the rat brain. Am. J. Physiol. 272, 1712-1725, 1997.
Dinarello CA. Infection, fever, and exogenous and endogenous pyrogens: some concepts have changed. J Endotoxin Res. 10: 201-22, 2004.
Dogan MD, Ataoglu H, Akarsu ES. Effects of different serotypes of Escherichia coli lipopolysaccharides on body temperature in rats. Life Sci. 67, 2319–2329, 2000.
Elmquist JK, Scammell TE, Saper CB. Mechanisms of CNS response to a systemic immune challenge: the febrile response. Trends Neurosci. 20, 565-570, 1997.
Kluger MJ. Fever: role of pyrogens and cryogens. Physiol. Rev. 71, 93-127, 1991.
Li S, Wang Y, Matsumura K, Ballou LR, Morhan SG, Blatteis CM. The febrile response to lipopolysaccharide is blocked in cyclooxygenase-2 -/-, but not in cyclooxygenase-1 -/- mice. Brain Res. 825, 86–94, 1999.
Long NC, Morimoto A, Nakamori T, Muraki N. The effect of physical restraint on IL-1h and LPS-induced fever. Physiol. Behav. 50, 625–628, 1991.
Rowsey, PJ, Gordon CJ. A peripheral mechanism of fever: differential sensitivity to the antipyretic action of methyscopolamine. Auton. Neurosci. 85, 148–155. 35, 243–248, 2000.
Schwartz JI, Chan CC, Mukhopadhyay S, Mcbride KJ, Jones TM, Adcock S, Moritz C, Hedges J, Grasing K, Dobratz D, Cohen RA, Davidson MH, Bachmann KA, Gertz BJ. Cyclooxygenase-2 inhibition by rofecoxib reverses naturally occurring fever in humans. Clin. Pharmacol. Ther. 65, 653– 660, 1999.
Soszynski D. The inhibition of nitric oxide synthase suppresses LPS- and psychological-stress-induced fever in rats. Physiol. Behav. 72, 65–72, 2001.
Souza FR, Souza VT, Ratzlaff V, Borges LP, Oliveira MR, Bonacorso HG, Zanatta N, Martins MAP, Mello CF. Hypothermic and antipyretic effects of 3-methyl- and 3-phenyl-5-hydroxy-5-trichloromethyl-4,5-dihydro-1H-pyrazole-1-carboxyamides in mice.European Journal of Pharmacology 451, 141– 147, 2002.
Taniguchi Y, Yokoyama K, Inui K, Deguchi Y, Furukawa K, Noda K. Inhibition of brain cyclooxygenase-2 activity and the antipyretic action of nimesulid. Eur. J. Pharmacol. 330, 221– 229, 1997.
Tolchard S, Hare AS, Nutt DJ, Clarke G. TNF alpha mimics the endocrine but not thermoregulatory responses of bacterial lipopolysaccharide (LPS): correlation with FOS-expression in the brain. Neuropharmacology 35, 243–248.
Tsushima, H., Mori, M., 2000. In vivo evidence that activation of tyrosine kinase is a trigger for lipopolysaccharide-induced fever in rats. Brain Res. 852, 367– 373, 1996.
Watanabe T, Saiki Y, Sakata Y. The effect of central angiotensin II receptor blockade on interleukin-1h- and prostaglandin E-induced fevers in rats: possible involvement of brain angiotensin II receptor in fever induction. J. Pharmacol. Exp. Ther. 282, 873-881, 1997.
Yang WW, Krukoff TL. Nitric oxide regulates body temperature, neuronal activation and interleukin-1h gene expression in the hypothalamic paraventricular nucleus in response to immune stress. Neuropharmacology 39, 2075–2089, 2000.
|